CONTINUOUS CRYSTALIZATION
We have significant expertise converting batch crystallizations to continuous ones. Through the use of in-line PATs, including ReactIR, FBRM, and Raman spectroscopy, we can determine the rates of nucleation and crystal-growth to create robust and reliable crystallizations systems.
OUR CRYSTALLIZATION SOLUTIONS
Mixed-Suspension, Mixed-Product Removal (MSMPR) Crystallization: The most simple and general system to perform crystallizations, a multi-stage MSMPR crystallizer is typically utilized to convert batch crystallizations to continuous ones.
Heterogeneous Crystallization: API in different solutions can be crystallized on crystalline or polymeric excipients to eliminate downstream processes such as granulation.
Integrated Nucleator and Tubular Crystallizer: A supersaturated solution is run into a nucleator device containing a specific seed initiating the nucleation process. Particles are then transferred into a tubular (plug flow) crystallizer where growth occurs.
RELATED PAPER
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